Maximizing the number of Piezo using 8 CD405xB Multiplexers

hi, new arduino mega user building 64 key marimba.
in order many keys, adding multiplexers.

my goal able play (4) of 64 notes "at once" (because play 4 mallets etc)

does see issue using: ( dual-circuit 4x1 multiplexers (cd405xb)
                       • each multiplexer support 2 notes @ time (1 per circuit). 16 digital control pins needed this. , can assign each piezo notes on each bank of (4) not played @ same time.

essentially allow me play @ least (4) notes time unless (2) of notes happened within same bank of 4.   is best way go here?

thanks,

justin

what have not explained, want these multiplexers do - input, or output?

almost should using else such shift registers.

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